| Day | Date | Opponent | Location | TV | Outcome/Time |
| Thu | 11/02/2000 | The Universal All Stars (Exhibition) | Memphis, Tenn. | | W, 77-61
Recap | Stats |
| Wed | 11/08/2000 | Team Georgia (Exhibition) | Memphis, Tenn. | | W, 88-69
Recap | Stats | Archived Audio |
| Fri | 11/17/2000 | Temple | Memphis, Tenn. | ESPN | L, 67-62
Recap | Stats | Archived Audio |
| Thu | 11/23/2000 | Miami (Ohio) | Bayamon, Puerto Rico | WLMT-TV | W, 60-59
Recap | Stats | Archived Audio |
| Fri | 11/24/2000 | Stanford | Bayamon, Puerto Rico | ESPN | Recap | Stats |
| Sat | 11/25/2000 | Utah | Bayamon, Puerto Rico | WLMT-TV | L, 61-58
Recap | Stats | Archived Audio |
| Wed | 11/29/2000 | Tennessee-Martin | Memphis, Tenn. | WKNO-TV | W, 81-49
Recap | Stats | Archived Audio |
| Sat | 12/02/2000 | Arkansas | Fayetteville, Ark. | WLMT-TV | L, 74-68
Recap | Stats | Archived Audio |
| Tue | 12/05/2000 | Tennessee | Knoxville, Tenn. | WLMT-TV | L, 86-76
Recap | Stats | Archived Audio |
| Sat | 12/09/2000 | Mississippi | Memphis, Tenn. | WLMT-TV | L, 64-56
Recap | Stats |
| Thu | 12/14/2000 | Arkansas State | Memphis, Tenn. | WKNO-TV | W, 83-60
Recap | Stats | Archived Audio |
| Mon | 12/18/2000 | Christian Brothers | Memphis, Tenn. | WKNO-TV | W, 98-54
Recap | Stats | Archived Audio |
| Thu | 12/21/2000 | Miami, Fla. | Miami, Fla. | WLMT-TV | L, 66-57
Recap | Stats | Archived Audio |
| Wed | 12/27/2000 | Southern Miss | Memphis, Tenn. | WLMT-TV WKNO-TV | L, 75-67
Recap | Stats | Archived Audio |
| Sat | 12/30/2000 | Kansas State | Memphis, Tenn. | WLMT-TV WKNO-TV | W, 81-58
Recap | Stats | Archived Audio |
| Wed | 01/03/2001 | Howard | Memphis, Tenn. | WKNO-TV | W, 112-42
Recap | Stats | Archived Audio |
| Sat | 01/06/2001 | Houston | Houston, Texas | WLMT-TV | W, 86-78
Recap | Stats | Archived Audio |
| Sat | 01/13/2001 | DePaul | Chicago, Ill. | ESPN2 | W, 72-68
Recap | Stats | Archived Audio |
| Thu | 01/18/2001 | Saint Louis | Memphis, Tenn. | ESPN | W, 72-63
Recap | Stats | Archived Audio |
| Sat | 01/20/2001 | Houston | Memphis, Tenn. | WKNO-TV | W, 72-68
Recap | Stats | Archived Audio |
| Wed | 01/24/2001 | Tulane | New Orleans | | W, 91-69
Recap | Stats | Archived Audio |
| Sat | 01/27/2001 | UAB | Birmingham, Ala. | WLMT-TV | W, 76-73
Recap | Stats | Archived Audio |
| Fri | 02/02/2001 | Marquette | Memphis, Tenn. | ESPN | L, 71-65
Recap | Stats | Archived Audio |
| Wed | 02/07/2001 | South Florida | Tampa, Fla. | WLMT-TV | W, 100-89
Recap | Stats | Archived Audio |
| Sat | 02/10/2001 | Tulane | Memphis, Tenn. | WLMT-TV WKNO-TV | W, 91-64
Recap | Stats | Archived Audio |
| Thu | 02/15/2001 | Cincinnati | Memphis, Tenn. | ESPN | L, 66-65
Recap | Stats | Archived Audio |
| Sat | 02/17/2001 | Charlotte | Charlotte, N.C. | ESPN+ | L, 83-76
Recap | Stats | Archived Audio |
| Mon | 02/19/2001 | UAB | Memphis, Tenn. | WKNO-TV | W, 86-69
Recap | Stats | Archived Audio |
| Sun | 02/25/2001 | South Florida | Memphis, Tenn. | ESPN2 | W, 79-61
Stats | Archived Audio |
| Wed | 02/28/2001 | Southern Miss | Hattiesburg, Miss. | WLMT-TV | L, 74-55
Recap | Stats | Archived Audio |
| Sat | 03/03/2001 | Louisville | Louisville, Ky. | ESPN+ | L, 65-56
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Thu | 03/08/2001 | Marquette (Conference USA Quarerfinals) | Louisville, Ky. | ESPN+ | W, 71-64
Recap | Stats | Archived Audio |
| Fri | 03/09/2001 | Cincinnati (C-USA Tournament) | Louisville, Ky. | ESPN+ | T, 89-79
Recap | Stats | Archived Audio |
| Tue | 03/13/2001 | Utah(NIT Tournament) | Utah | ESPN | W, 71-62
Recap | Stats | Archived Audio |
| Tue | 03/20/2001 | UTEP (Second Round - NIT) | Memphis, Tenn. | WLMT-TV | W, 90-65
Recap | Stats | Archived Audio |
| Thu | 03/22/2001 | New Mexico (Third Round - NIT) | Memphis, Tenn. | | W, 81-63
Recap | Stats | Archived Audio |
| Tue | 03/27/2001 | Tulsa (Semifinals - TiVo NIT) | New York, NY | ESPN | L, 72-64
Recap | Stats | Archived Audio |
| Thu | 03/29/2001 | Detroit (3rd Place Game - TiVo NIT) | New York, NY | ESPN | W, 86-71
Recap | Stats | Archived Audio |
